Development of medical devices based on functionalized nanofibers for application in biomodels

Provider: MPO

This project was implemented in the category of collective research and is divided according to its research focus into three sub-projects, which are described below. A number of small and medium-sized enterprises and research institutions participated in the implementation of the project. The project was successfully completed and the set goals were met in full.

Research of input materials and methods of their modification for the preparation of advanced functionalized nanofibrous structures with regard to target applications in the field of biomedicine and industry

The aim of this sub-project was the research of input substances and technologies that enable advanced functionalization of nanofibrous structures with regard to target applications. The implementation of this sub-project took place in three interrelated research directions. The first of them is the identification of suitable input monomers and polymers containing substitution groups enabling the subsequent functionalization of spun polymers using chemical and biologically active substances. The second research direction represented the synthesis of a polymer (polyurethane), which contains suitable substitution groups for subsequent functionalization, and at the same time, in terms of qualitative parameters, it will be suitable for innovative applications in the field of biomedicine, food industry, sanitation technologies and others. The last research direction is the specific functionalization of polymer solutions and nanofibrous structures, even in combination with nanoparticles and other additives in order to improve their physical and functional properties. Eligible expenses were partially supported by the Operational Program Entrepreneurship and Innovation for the Competitiveness of the Cooperation - Clusters call for research works falling within the category of industrial research.

The lightweight textile composite materials research with an integrated nanofibrous layer and purely nanofibrous linear materials with specific functional properties for industrial application areas

The research work of the sub-project is mainly aimed at the development of procedures and the selection of specific materials that will enable the production of lightweight laminates in order to achieve the required mechanical properties, increase the antimicrobial and anti-allergic efficiency and support their self-cleaning ability, and to optimize the mass representation of the nanofibrous layer, the strength and productivity of linear composite or purely nanofibrous structures for specific input materials for the field of industrial applications.

Research and development of a combined material based on atomized nanoparticles from biological material obtained from mesenchymal stem cells and functionalized nanofibrous structures for applications in medicine

The goal of this project was the research and development of a preparation that would significantly accelerate the regeneration of damaged tissues. Primarily, it concerns the healing of wounds, including burns, burns and wounds from the application area of open defects of the abdominal wall, which arise as a result of complicated healing after surgical procedures, and in which it is difficult to achieve full integrity of the abdominal wall again by classical methods. Research work focused on the use of the therapeutic potential of endogenous material obtained from mesenchymal stem cells (MSC). This biological material was converted into the form of nanoparticles using the atomization method, which were subsequently incorporated into the nanofibrous structure. Eligible expenses were partially supported by the Operational Program Entrepreneurship and Innovation for the Competitiveness of the Cooperation - Clusters call.